List the basic steps to performing a GWAS. The figure below is from Reitveld et

Question

List the basic steps to performing a GWAS.

  The figure below is from Reitveld et al.’s (2013) study entitled “GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment”. What is the probability that alleles at locus rs9320913 are associated with educational attainment purely by chance (either as a raw decimal or a percent) [note: y-axis = LoD]? probability that alleles at locus rs9320913 are associated with educational attainment by chance is 0.05/126559 = 3.95 x 10-7

rs9320913 100 rs9320913 10 0.8 06 -80 04 0.2 60 40 20 POU3F2 C6orf168 MIR2113- KLHL32 FBXL4 C6orf167 99.5 98.5 Position on chr6 (Mb) 98 97.5

Explanation / Answer

Answer

Recombination rate shows the distance between the alleles in the locus rs9320913 is associated with educational achievement in the CM unit.

The low Cm valve (blue dot) shows high likelihood of association of alleles in the locus rs9320913 are associated with educational achievement.

there blue dot freudience is 0.2.

so,

0.2 = 1/5 = 20% probability

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