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One type of hemophilia is caused by a mutation caused by an insertion a transpos

ID: 150035 • Letter: O

Question

One type of hemophilia is caused by a mutation caused by an insertion a transposon into the wild type allele of the HBA gene. The figure below shows a chromosome before transposition (top) and after transposition (bottom). WT- wild type or normal copy of the gene TE - transposable element WT HBA gene TE Mutant HBA gene TE What type of transposition event likely caused the mutant HBA gene (as shown in the diagram above) O A) retro-transposition E) All of the above O B) simple transposition 0 D)Aor c could be correct C) replicative transposition 25 2

Explanation / Answer

Answer: Option D

Explanation: In Retrotransposition, the respective transposon sequence gets transcribed into an mRNA and then reverse transcribed into cDNA. It then gets incorporated into the genomic DNA. So, in those scenario we could observe two transposon. In replicative transposition, the transposon gets replicated along the gDNA during replication. The newly replicated transposon is cut out and gets transposed into a new locus. Also, in this scenario we could observe two transposon.

Simple transposition does not involve any of these process.In simple transposition, the transposon at one site is cut out and gets transposed into new locus leaving no trace.

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