1. Which residue plays an important role in the stabilization of the transition
ID: 149037 • Letter: 1
Question
1. Which residue plays an important role in the stabilization of the transition state?Nucleoside phosphorylases Nucleoside phosphorylases (NP) are among the key enzymes in the nucleotide salvage pathway, allowing for more efficient recycling of nucleosides. The enzymes catalyze the cleavage of nucleoside glycosidic bonds to yield a free nucleobase and ribose (or 2'deoxyribose) 1-phosphate as shown below. The purine is recycled or oxidized to uric acid for excretion. -d 10 The following figure shows the interactions of active site residues with the substrate. 9. 181 HN G20 I. Which residue plays an important role in the stabilization of the transition state? Propose a transiti on-state inhibitor for this enzyme 2.
Explanation / Answer
Answer- (1) Salvage pathway is the recycling of purines formed by degradation of nucleotides nucleosides and deoxynucleosides are salvaged .phosphoribosyl phosphate is the substrate along with nucleoside . Adenine phosphoribosyl transferase and hypoxanthine guanine phosphoribosyl transferase are the enzymes involved in it.
Answer(2)Transition state inhibito for this enzyme is antimalarial drug . It inhibit utilisation process by plasmodium species by inhibition transition state .
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