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1. Adenovirus viral protein E1A, HPV viral protein E7, and SV40 protein LT targe

ID: 148892 • Letter: 1

Question

1. Adenovirus viral protein E1A, HPV viral protein E7, and SV40 protein LT targets which protein specifically?

Rb

p53

p21

pTp

2. Which statement about viral DNA synthesis is NOT correct?

DNA viruses encode at least one protein involved in DNA synthesis

DNA is synthesized in a 5’-3’ direction

Quiescent cells ensure exponential and efficient viral DNA replication

Viral DNA replication is delayed after infection due to the synthesis of at least one viral protein

3. In general, viral fusion peptides are exposed for insertion into the membrane when

the virus particle is in the cytoplasm

the virus is docked on the nuclear pore complex (NPC)

the virus particle is near a cell due to electrostatic forces

the endosome becomes acidified

Rb

p53

p21

pTp

Explanation / Answer

Answer-1(a) Adenoviral protein E1A and HPV viral protein E7 and SV40 protein LT target RB gene because this attraction cause cells to undergo replication so that viral components can be synthesized.

Answer-2(c)viral DNA synthesis donot occur well in quiescent cells because quiescent cells are those which reversibly arested in cell cycle so these cells donot undergo dna replication so that viral dna can not be replicated.

Answer-3(c) viral fusion proteins are exposed when virus near about the cell because this promote entry of virus particle into the cell .