Jenny (a 40 year old woman), Arun (a 45 year old man), and Sydni (a 47 year old

Question

Jenny (a 40 year old woman), Arun (a 45 year old man), and Sydni (a 47 year old woman) are siblings with the same mother and father. Sydni and Arun have been diagnosed with breast cancer, and their type of breast cancer is associated with the BRCA2 breast cancer allele. Jenny has not been diagnosed with breast cancer. Offer at least 2 hypotheses explaining this difference among the siblings. Why do 2 siblings have breast cancer, while the 3rd sibling does not? What are two possible hypotheses? Hypothesis A: Hypothesis B:

Explanation / Answer

1.Jenne didnot inherit a mutated gene BRAC2 gene then they have a extremely low chances of developing breast cancer. she is having a homozygous recessive for BRAC2 gene.the cancer risk caused by mutation are inherited in dominant gene,and the affected person should be in heterozygous in nature to get mutation.

2. she doesnot have a braest cancer yet but has a high chances to get, because she is not old enough to gene to have mutated gene, she is the younest one.risk increases significantly after age 50.

Related Questions

Navigate

• Browse (All)
• Browse J
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.