2. Write a paragraph of 3-5 sentences answering the following questions. Your re

Question

2. Write a paragraph of 3-5 sentences answering the following questions. Your response should first answer the question and then go onto state physiological interpretation's behind your answer. Paragraphs that demonstrate complete and thorough reasoning will receive full points.

You discover a drug that prevents voltage-gated Na+ channel inactivation gates from opening when they are closed but has no effect on inactivation gates when they are open. What would happen to the action potential in a neuron exposed to this drug? Explain your answer. Assume the neuron is at resting membrane potential (e.g., -70 mV) at the time it is exposed to the drug.

Explanation / Answer

Action potential will not be generated because it require opening of voltage gated sodium channel to reach the firing level the flow of sodium along its concentration gradient.

It overcomes the repolarization and runs away depolarization effect.

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