Tell me what you want to do 1 Normal 1 No Spac. Heading 1 Heading2 Title Subrtit

Question

Tell me what you want to do 1 Normal 1 No Spac. Heading 1 Heading2 Title Subrtitle Sulbtie Em..Emphasis Intens Strong Paragraph 1. Paul has been taking a drug for a long period of time. His response has been measured over time and has generated the following graph. The arrows indicate the time of administration. Why is his response decreasing? Be as specific as you can. 12 pts] Effect 2. Sally is diagnosed with pneumonia after examination by her doctor. Her symptoms are cough and shortness of breath. Given the severity of her symptoms, the doctor feels that treatment with to started immediately. A therapeutic concentration of 4mg/L is desired as quickly as possible. Tobramycin distributes to extracellular fluid and has a tiz of 7.5 hours. What is the loading dose for the required? [2 pts] should be Steve is prescribed a drug to take orally that is 500 mg. Only approximately 82mg is actually absorbed trom the gastrointestinal tract 3 pts] 3. a. What is the bioavailability? b. The drug also undergoes biotransformation through Phase lI reactions in the liver. What is the major role of Phase ll biotransformation? c. Do you think that oral administration is the best method of administration? Explain your answer English States) to search

Explanation / Answer

1. The effect of drug is decreasing with its repeated use due to drug tolerance. Paul's body adapts to diminish the response of the particular drug due to repeated dose/use of it. However, a higher dose of the drug may again amplify its effect, but there is a possibility that tolerance may also increase.

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