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please explain clearly. I\'m not sure how the formamide will compare to a compet

ID: 148032 • Letter: P

Question

please explain clearly. I'm not sure how the formamide will compare to a competitive Inhibitor like 4methylpyrazole. if formamide is better can you say how and why pls and also do the graph and explain

e. A class of compound called formamide has been shown to be an uncompetitive inhibitor for the enzyme ADH. How would then the Lineweaver-Burk plot of methanol conversion look when there is some formamide present? Will it look exactly like the line when there is some ethanol present (so the top line in the h above)? If not, then please sketch the line of methanol conversion when

Explanation / Answer

We known that formamides are unreactive analogous of the aldehydes substrate of alcohol.But they bind th the enzymes NADH complex and are uncompletitive inhibitor against varied concentration of alcohol

When we study about evaluation of inhibitor with purified enzymes.We detwrmines that inhibition constant for the series of -substitute formamides,pyrozyle by initial velocity atudies with varied concentration of the inhibitor and a substrate appropriate for each purified alcohol dehydrogenese