Which of the following statements is false? a Src is a tyrosine kinase ob Amplif

Question

Which of the following statements is false? a Src is a tyrosine kinase ob Amplification of the myc gene is associated with a poor prognosis, because the cells express enough myc protein to proliferate even in the absence of mitogens Oc Mutations in the Kit receptor are seen in familial cancer syndromes d. Cytoskeleton-associated proteins are ligands for integrins o e In the JAK-STAT pathway, ligand binding promotes phosphorylation, dimerization and nuclear translocation of transcription activátors

Explanation / Answer

ANSWER-) D is FALSE, You are right!

Cytoskeleton proteins include tubulin (component of microtubules), Actin (microfilaments) , Lamin (Intermediate filaments) .

Ligands of Integrin are mostly found in extracellular matrix. Collagen, Laminin, Fibronectin, Vitronectin are Ligands of Integrin.

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Src belongs to a family of non-receptor tyrosine kinase.

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Amplification of myc gene is associated with poor prognosis…because cells express enough myc protein to proliferate even in absence of mitogens. A region of Myc protein is able to substitute a crucial transcription factor thus raising its possible expression levels.

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KIT is a receptor tyrosine kinase. Mutations in Kit gene are related to Familial cancer syndromes like Gastrointestinal stromal tumor.

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In JAK-STAT pathway ligand binding promotes dimerization, Phosphorylation and subsequent translocation.

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