True or False? a. Osteogenesis imperfecta is a dominant disease caused by defect

Question

True or False? a. Osteogenesis imperfecta is a dominant disease caused by defects in keratin structure b. Anti-parallel B-sheets are more often seen in proteins than parallel B-sheets c. y(psi) is the measure of the rotational angle of the bond between the carbon and the neighboring nitrogen in a peptide. d. The amino acid, F, causes bends in an amino acid sequence. e. The most common form of double-stranded DNA is the A-form. f. The "template" and "non-coding" strand are the same. g. The enzymatic conversion of RNA to DNA is called reverse transcription. Loss of HCO; due to severe diarrhea would likely results in alkalosis.

Explanation / Answer

a. Osteogenesis imperfecta is a dominant disease caused by defects in keratin structure.

Ans: False.

Osteogenesis imperfecta ia an autosomal recessive pattern of inheritance caused due to mutation in CRTAP gene.

b. Anti-parallel beta sheets are more often seen in proteins than parallel beta sheets.

Ans: True. because the hydrogen bonding is slightly more stable in antiparallel beta sheets than in parallel beta sheets.

c. Psi is the measure of the rotational angle of the bond between the alpha carbon and the neighbouring nitrogen in a peptide.

Ans: False. Psi is the angle between alpha carbon and carbonyl group.

e. The most common form of double stranded DNA is the A-form.

Ans: False.

The most common form of double stranded DNA is B- form.

f. The template and non-coding strand are the same.

Ans: True.

g. The enzymatic conversion of RNA to DNA is called reverse transcription.

Ans: True. This process occurs in Retroviruses with the help of an enzyme called as Reverse Transcriptase.

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