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As is sometimes the case in observational studies, when the results of the Women

ID: 147516 • Letter: A

Question

As is sometimes the case in observational studies, when the results of the Women's Health Initiative (WH) study of Hormone Replacement Therapy IHRT) were analyzed Women who were compared in the observational studies were different in several factors that could have masked the negative effects of the treatment . The observational studies were done in rare populations, such as the inuit, so the results did not apply to the general popula . The observational studies did not test t he correct formulation of the hormone compared to the accurate work done in the HRT trials The wrong statistics were used in the observational-studies. Question 3 Prior to the initiation of the Women's Health Initiative (WHI) study of Hormone Replacement Therapy (HRT), the arguments against . It was unethical to fail to give a known successful treatment to a group of study participants starting a study with a placebo group included All of these answers are correct . The prior studies did not have placebo group so the studies could not be directly compared. The side effects were minimal in comparison to the benefits demonstrated in prior studies Over half of all American women, ages 50-65, were taking the therapy already Question 4 The Data Safety Monitoring Board stopped the WHI study of hormone replacement early because: They agreed that it was not ethical to give a placebo to some of the participants. . The risks of the therapy exceeded the benefits. . The benehts outweighed the risks and the conclusion was that it was safe for any woman to take the hormone treatment. .The cost of the drug was prohibitive so women could not afford the treatment, even if the study showed the treatment was b enecial

Explanation / Answer

2.The first option is the correct one ,because WHI results were analyzed regarding major health issues causing morbidity, mortality,in post menopausal women.This event is particularly to decrease coronory events in post menopausal women is observational studies such as heart, estrogen, replacement study and women health WHI,showed that such therapy had high risk of aide effects and complications.

3.All the above options given are correct.

4.The data safety monitoring board stopped the WHI,study of HRT early because excessive risk of breast carcinoma.

Option :b holds the correct one.

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