Zoom showing a highly schematic drawing of the key interactions that are broken

Question

Zoom showing a highly schematic drawing of the key interactions that are broken going between the T- and R-state crystal structures. Here the B-globins (blue) are transparent so that interactions at the a-globin (pink) N-termini can be visualized B2 V34 a, K40 , R141 82 V34 OB H146 B2 D94 a, R141 2 D126 K40 2 D94 a, K127 a2 K127 H146 interactions Key interactions are formed at the -termini in the T state Key interactions are formed at the -termini in the T state. Key interactions at the B-termini are disrupted in the R state. Key interactions at the -termini are disrupted in the R state

Explanation / Answer

The estimate pKa may be 6.0. Becuase pH pKa is property of compound that tell us how acidic it is.

Lower pKa have high acidic nature. In the heamoglobin, the pKa value of histidine will be 7.8 and pKa of free histidine will be 6.2. In HbCO A , His FGA beta has a pKa value of about 6.6 characteristic of free histidines at the surface of protiens.

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