presence or absence of cytoplasmic granules. d. The e granulocyte group includes
ID: 145214 • Letter: P
Question
presence or absence of cytoplasmic granules. d. The e granulocyte group includes the following cell types: T cell, B cells, and monocytes. The oncologist has confirmed the diagnosis of AML, which is a type of cancer in which the bone marrow makes abnormal myeloblasts (a white blood cell precursor), erythrocytes, or platelets. (a) Which specific group of white blood cells would you expect to be affected by AML? (Hint: Discuss the difference between the leukopoiesis of the myeloid and lymphoid cell lines.) (b) How might each of these cells from the myeloid cell line be associated with the following symptoms from DH's presentation: abnormal bleeding, frequent infections, and anemia? 2.Explanation / Answer
Acute Myeloid Leukemia (AML) is also known as acute myelocystic leukemia, acute granulocytic leukemia. It is a type of cancer of myeloid line of blood cells which build up in abnormal amount in bone marrow inetefering with normal blood cells. Leukopoiesis is process of development of WBC from bone marrow. Bone marrow produces RBCs, WBCs and platelets. RBCs carry oxgen to the organs of the body and helps in performing bodily function. Decrease in number of RBC ca lead to anaemia. Platelets can important in stopping blood. Lacking in number of platelets can make one prone to bleed or cut easily. WBCs are the cells that help body to fight off infections. Lack of WBCs in the body can make it weakened. This can even lead to reccuring infections. WBC can be of many types: Lymphocytes are major part of immune system since they help in tackling with infections. Two major types of lymphocytes are B-cells which protect body from infections by producing antibodies against them. Other one is called T-cells which help body fight viruses and strengthen the immune system. Other type of WBCs other than lymphocytes, are monocytes these circulate in blood and engulf germs, bacteria present in the body. Two types of monocytes are macrophages and dendritic cells. Granulocytes are infection-fighting cells which cantain enzymes and other substances that destroy pathogens. Any blood forming cells from bone marrow whether or not it is myeloid or lymphoid cells can be converted into a leukemic cells halting their maturation process and resistance to death. This weakens the immune system by stopping defense system of the body against infections. Leukemic cells are derived from White blood cells precursors which makes individuals more susceptible to infections. This can cause abnormal bleeding since it affects WBC platelets, decreased number of platlets can lead to adnormal bleeding and cuts. Frequent infection since body's immune system is weakened so any common infection which could previously be avoided by immune system can now be jeopardized. A person suffers from anaemia when diagnosed with AML since This leads to reduced amount of RBCs in blood. RBC is used to carry oxygen to to th organ without which person can become anaemic.
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