Hemophilia is a genetic disease that has plagued the royal houses of Europe sinc

Question

Hemophilia is a genetic disease that has plagued the royal houses of Europe since the time of England's Queen Victoria was a carrier. Her granddaughter Alexandra married Nicholas II, the last tsar of Imperal Russia. Nicholas ws normal. THeir son, Tsarevich Alexis, was afflicted with this disease. Alexix and his four sisters are all thought to have been killed at the outbreak of the revolution of 1917. It is likely that:

(a) all four sisters were fully normal with regard to hemophilia
(b) one or more of the sisters may have been a carrier of hemophilia
(c) all of the sisters were carriers of hemophilia
(d) one or more of the sisters may had hemophilia
(e) all of the sisters had hemophilia.


Please explain

Explanation / Answer

B- Since the hemophilia trait is carried on the X chromosome, women need 2 copies of the mutated gene, while men only need one so it is likely that at least one of the sisters was a carrier of the gene.

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