Article: Metabolic syndrome and extensive adipose tissue inflammation in morbidl

Question

Article: Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs

https://ac.els-cdn.com/S2212877818303004/1-s2.0-S2212877818303004-main.pdf?_tid=8aa26dea-4107-4dec-8f3f-a132bf171bf9&acdnat=1537052321_76c00462dae879a3de541d3dc40d177b

I'm having a hard time reading this article and understanding what its saying. Can anyone 1) summarize it for me, 2) explain the biological concepts that you found (ex. I found obesity, and diabetes), and 3) what is the association between the study and public health? Thank you very much!

Explanation / Answer

!) Summary of the article.

The purpose of this article is to understand obesity and see the correlation between obesity and diseases which make up the Metabolic Syndrome (such as diabetes, cancer, and hypertension). To understand the severe effects extra body weight can have on organs in the body, and animal study was done using mice.

First, obesity was induced in these mice using a High Fat, High Energy (HFHE) diet. Before being put on this diet, the mice had variation in their body masses. After being put on this diet, they were all similarly obese.

A symptom of obesity is chronic inflammation of adipose tissue. On extreme level, necrosis (cell death) can occur in visceral but not subcutaneous tissue.

The reason these authors are interested in research on this topic is because obesity is a growing epidemic.

Storage of excessive fat can lead to insulin resistance. This condition is accompanied by adipocyte death, abnormal fat tissue remodelling and fibrosis in necrosis.

This is backed by the experimentation on which this article is written.

The figures in the article show obesity at different weeks and the measures of other diseases at corresponding times.

2) the biological concepts can be found in the results.

I will list them here.

3. The association between the study and public health is that obesity is a worldwide epidemic. The worldwide prevalence of obesity has increased to 10% in men and 15% in women. The prevalence of obesity is persistently increasing worldwide, and the magnitude has nearly doubled in more than 70 countries since 1980. In 2015, approximately 604 million adults were considered obese. Obesity, in turn, causes various complications which are collectively called the Metabolic Syndrome or Syndrome X. (hyperglycemia, hypercholestemia, hypertension and obesity). These are major risk factors for cardiovascular disease and can result in increased mortality.

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