Figure 2 shows what happens to mast cells’ ability to respond to salbutamol or t

Question

Figure 2 shows what happens to mast cells’ ability to respond to salbutamol or terbutaline following a prior exposure to these drugs. What happens and what is this type of response called (1)?

Desensitization induced by B-adrenoceptor agonists The investigator next determined the effects of long-term (24 h) treatment of HLMC with sub-maximal and equi-effective concentrations of either salbutamol (107 M) or terbutaline (107 M) on the subsequent ability of salbutamol and terbutaline (10 +104 M) to inhibit histamine release (Figure 2) 50 -control control salbutamol 40 40 salbutamol 30-terbutaline 30-0-terbutaline 20 20 10 -98 -7 6 5 4 10 98 7 -6 5-43 log [salbutamo (M) log [terbutaline] (M) Figure 2: Functional desensitization of -adrenoceptor agonist-mediated responses in mast cells. HLMC were incubated 24 h without (control) or with either salbutamol (10-7 M) or terbutaline (10-7 M) and then washed extensively. Cells were then incubated without or with either salbutam ol (a) or terbutaline (b) for 10 min before challenged with anti-lgE to induce histamine release. Values are expressed as the per cent inhibition of the control histamine release and are the means + standard error of the mean, n= 14

Explanation / Answer

ANS) The impacts of isoprenaline, terbutaline and salbutamol on the IgE-interceded arrival of histamine from Human Lung Mast cells result in three -adrenoceptor agonists hindered histamine discharge. Terbutaline and salbutamol were basically equipotent as inhibitors of histamine discharge however approximately 10 crease less intense than isoprenaline having both terbutaline and salbutamol showed variable inborn exercises among Human Lung Mast cells arrangements going about as full agonists, with respect to isoprenaline, in five for salbutamol and nine for terbutaline. By and large, terbutaline was marginally more solid than salbutamol r=0.78 between the inborn exercises of terbutaline and salbutamol among HLMC arrangements.

Therefore after exposure of drugs isoprenaline, salbutamol and terbutaline all at 105 m on cAMP age in HLMC were resolved. Terbutaline and salbutamol creating comparable levels of aggregate cAMP in these cells and about a half of the sum produced by isoprenaline.

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