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PDF File PDF File PDF File PDF File PDF File Microsoft Word Microsoft Word PNG File (1) Enzyme X has an ionizable side chain in its active site and is therefore regulated by pH. Given the velocity versus pH diagram for Enzyme X below, which statement is correct? (2pts) 2 4 6 8 10 A. This enzyme works best when the side chain is positively charged B. This enzyme works best when the side chain is negatively charged. C. The addition of H+ ions will activate Enzyme X. D. The ionizable side chain appears to have a pKa of 10. E. The ionizable side chain is likely critical for forming an ionic bond with the side chain of a glutamate or aspartate residue + 100% Show all Class8 Enzyme Re...pdf

Explanation / Answer

Answer ) Enzymes works best when side chain is negatively charged.

Because suppose aspartate and glutamate are negatively charged residues at physiologial pH. Because of short side chain the carboxyl group of Asp is rather rigid With respect to main chain. This can be tbe readon by which carboxyl group only binds to Asp than Glu.

Suppose a positive charge lysine and avginine, are also ar rhe molecular surfaces. They are long and flexible and possess different conformation. and cause very difficulty.

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