Question 6. (a) Using the table of AA propensities from the book, rate each of t

Question

Question 6. (a) Using the table of AA propensities from the book, rate each of the three peptides below for its likelihood to be found in either an a-helix or a ß-sheet, by adding up the values for each amino acid in each conformation. (b) Now, check each peptide for "sequence busters" - amino acids and groups of amino acids that are hardly ever found in helices or sheets (these are listed in the text). (c) Pick the one sequence most likely to be in a helix and the one most likely to be in a sheet and justify your choice based on your work above in (a) and (b). (a) CRAGNRKIVLETY (b) SEDNFGAPKSILW (c) QKASVEMAVRNSG

Explanation / Answer

Peptide C> peptide A> peptide B

The presence charged residues Lyc, Glu, Ala on one face of the helix , makes it to form alpha helix ..

Peptide A contains base residues Arg and Lys which destabilizes the helix

B contains Gly and Pro which are helix breakings

B:- Gly and Pro are the sequence busters , present in peptide B

C:-peptide C is most likely to be in helix and B which breaks the helix and be in sheet

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