Multiple choice. 1.Origins of replication... A. occur at many sites on bacterial
ID: 144219 • Letter: M
Question
Multiple choice.
1.Origins of replication...
A. occur at many sites on bacterial and human chromosomes
B. contain one replication fork each where the daughter stands are being sythesized
C. initiate replication in a uni-directional manner
D. result in bubbles opened by helicases
E. occur at one site per chromosome
2.Telomerase...
A. is important for the replication of circular chromosomes
B. is important for the replication of linear chromosomes
C. carries a template in the form of a DNA molecule
D. sythesizes RNA primers
E. both the 1st and 2nd option are correct
3.What are topoisomerases?
A.Enzymes that lay down an RNA primer during DNA synthesis.
B.The ends of the chromosomes.
C. Proteins that unwind DNA.
D. A strain of mice.
4.Which enzyme produces the first piece of nucleic acid synthesized in DNA replication?
A. Primase
B. DNA polymerase
C.ORC
D. DNA ligase
5. Which of the following does not contribute to the mutagenesis of our DNA?
A. alterations to bases (nucleotides) that change their hydrogen bonding characteristics
B. passing on of mismatched DNA into daughter cells
C. inefficiency of MutS to recognize errors in base pairing
D. DNA polymerase slipping during synthesis and creating insertions or deletions
E. DNA polymerase erroneously synthesizing DNA in the reverse direction during S phase
A. is important for the replication of circular chromosomes
B. is important for the replication of linear chromosomes
C. carries a template in the form of a DNA molecule
D. sythesizes RNA primers
E. both the 1st and 2nd option are correct
3.What are topoisomerases?
A.Enzymes that lay down an RNA primer during DNA synthesis.
B.The ends of the chromosomes.
C. Proteins that unwind DNA.
D. A strain of mice.
4.Which enzyme produces the first piece of nucleic acid synthesized in DNA replication?
A. Primase
B. DNA polymerase
C.ORC
D. DNA ligase
5. Which of the following does not contribute to the mutagenesis of our DNA?
A. alterations to bases (nucleotides) that change their hydrogen bonding characteristics
B. passing on of mismatched DNA into daughter cells
C. inefficiency of MutS to recognize errors in base pairing
D. DNA polymerase slipping during synthesis and creating insertions or deletions
E. DNA polymerase erroneously synthesizing DNA in the reverse direction during S phase
Explanation / Answer
1) Origins of replication is a specific sequence in the genome of an organism where DNA replication is initiated. It consists of a replication fork which is formed by unwinding of double strand DNA by the action of enzyme helicase. The daughter strands are produced from each strand of the unwinded DNA. Each will move in opposite direction from 3' to 5' end. Eukaryotes have multiple replication forks and origin of replication in a single linear chromosome. So, the answer for this question is option D (results in bubbles opened by helicase).
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