1) The genome of a marine bacterium has been determined to be 1830Kbp. A total o
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Question
1) The genome of a marine bacterium has been determined to be 1830Kbp. A total of 1730 genes have been identified. What is the average spacing between the midpoints of genes?2) Recent research shows that there is a 1.7% sequence difference between humans and chimpanzees. If the two genomes are the same size, how many nucleotide differences exist between the two species? 1) The genome of a marine bacterium has been determined to be 1830Kbp. A total of 1730 genes have been identified. What is the average spacing between the midpoints of genes?
2) Recent research shows that there is a 1.7% sequence difference between humans and chimpanzees. If the two genomes are the same size, how many nucleotide differences exist between the two species?
2) Recent research shows that there is a 1.7% sequence difference between humans and chimpanzees. If the two genomes are the same size, how many nucleotide differences exist between the two species?
Explanation / Answer
And-1) If there are 1730 genes equally spaced apart on one strand all along the genome then there are 1729 gaps between genes. The average distance between distance between genes is the space covered by one of these gaps.
Ans-2) Nucleotide divergence between 1 human and 1 chimp if the difference in the gene sequence is 1.7% is around approximately 48 million single nucleotide changes according to the rececnt research.
However, the number is inflated because some nucleotide variants are polymorphic within humans and chimps. The estimated propootion of fixed difference is approx 1%.
The above divergence is calculated from single nucleotide differences is aligned sequnces excluding gaps. These gaps in the alignment are caused by insertion or deletion of DNA bases also known as indels. There are approx 5 million small indel difference between human and chimp. If the sequence are counted as mismatches, the divergence between the two species is around 5%.
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