15. a-Fibrinogen is a protein found 1 in blood. Spectrum A shows the 80 electros

Question

15. a-Fibrinogen is a protein found 1 in blood. Spectrum A shows the 80 electrospray MS/MS spectrum of a 60 tryptic peptide of a-fibrinogen from a 40 healthy individual. Spectrum B shows the MS/MS spectrum of the samepeptide from a-fibrinogen obtained from an individual with1 pancreatic cancer 973.5 ESSSHXPGIAEFPSR 1110.6 506.3 665.3 bg 932.4 1132.5 b2 359.3 528.3 706,4 876.4 1003.4 1247.6 1279.5 989.5 80 60 126.5 a. The sequence of the peptide 40 in spectrum A is given except for 20 one residue, which is designated X. Based on the information in the spectrum what is X? In spectrum A above, circle the masses above the peaks that you used to determine X and show your calculation in the space below 506.3 1665.3 ya 359.2 bo1148.5 bi2 5 1019.31263.61295.5 1479.6 400 600 800 1000 1200 1400 1600 b. A single residue in this peptide is modified in the pancreatic cancer patient sample. Based on the changes in spectrum B compared to spectrum A, determine which residue is modified

Explanation / Answer

x denotes FGA gene ...peak no 3 shows the information of the spectrum

Chromosome 4 is modified as FGA gene causing various secretions and four transcriptions

Related Questions

Navigate

• Browse (All)
• Browse 1
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.