Apoptotic cells are efficiently phagocytosed by neighboring cells or macrophages

Question

Apoptotic cells are efficiently phagocytosed by neighboring cells or macrophages. Which of the following DOES NOT normally happen in this process?

Select one:

A. The apoptotic cell releases some of its cytoplasmic content to induce a local inflammatory response.

B. The apoptotic cell rounds up and detaches from its neighbors, which facilitates phagocytosis.

C. The apoptotic cell exposes phosphatidylserine at its surface, which interacts with receptor proteins on the surface of phagocytes via “bridging” proteins.

D. The apoptotic cell loses or inactivates “don't eat me” signals.

Explanation / Answer

Apoptotic cells usually detach from the substartum and rounds up to undergo phagocytosis.
These cells also expose some receptor protein which interact with phagocytic cells.
They also expose eat me signals on their surface.
They do not release some of the cytoplasmic content, but they release some mitochondrial
proteins which induce inflammtory signals.
Option A is the correct answer.

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