Biochem Amino Acids: Amino Acids 7. A peptide has the sequence Ala-Trp-Gly-Lys-A

Question

Biochem Amino Acids:

Amino Acids 7. A peptide has the sequence Ala-Trp-Gly-Lys-Ala-His-Val. (a) Write out the single letter sequence of the peptide. b) Calculate the percentage and indicate the charge of the predominant peptide species at pH 6.5. Discount any species that represent less than 1% of all species. Use the follow pKa values: pKa Lys-10.5, pKa N-terminus-9.3, pKa His 6.0, pKa C-terminus -4.3 (c) Draw the chemical structure of the predominant charged peptide species at pH 6.5. Clearly indicate charged groups. (d) Calculate the pI of the peptide.

Explanation / Answer

The single letter sequence of a peptide chain is.

Alanine -A

Tryptophan-G

Gly-G

Lys-K

Alanine -A

Histidine-H

Val-V

AWGKAHV

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