3.7 3.7 Based on the type of analysis in Exercise 3.6, if an investigator correl

Question

3.7 3.7 Based on the type of analysis in Exercise 3.6, if an investigator correlates the proliferation and migration of fibroblasts in an injured tendon with the value of axial stress during the test (e.g., no stress, nonzero but subphysiological stress, physiological stress, or supraphysiologic stress), how can one know that the mechanotransduction is induced by the exper- imentally convenient axial stress rather than the maximum shear stress given that both exist simultaneously (i.e., their calculation depends only on the choice of the coordinate system introduced by the investigator)?

Explanation / Answer

If the cell is subjected to any to any stress so that it changes the length/any dimension of the cell, then mechanotransduction is due to axial stress, otherwise it is due to shear stress.

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