Daily uinary IGA excretion in control and nitisinone-treated alkaptonaria patien
ID: 141458 • Letter: D
Question
Daily uinary IGA excretion in control and nitisinone-treated alkaptonaria patients over the course of lcaptonuria results from defects in the enzyme homogentisic acid dioxidase. As a result of this deficiency, homogentisic acid accumulates in the body and a lot it excreted in the urine. The graph ve shows the homogentisic acids levels in alcaptonuria patients that are being treated with the nitisinone vs control patients who did not get the drug Based on the above, is the drug effective in shutting down this pathway? Why do you say this? level nonec entisie acid once (casea in shec reasetus ment n tie eriod w hch shous eiectiviness tt drug The patients ranged in age from 40 to 65, and all had severe arthritis and polymer deposits in their tissues. Unfortunately, the drug did not improve their conditions. Why might this be so?Explanation / Answer
Low dose of nitisinone is effective in treating alcaptoneuria, as the graph shows the decreasing level of homogentisic acid.
This drug treat arthritis if it is taken for a long term.
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