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sota State University, Moorhead-BIOL 341-Fall18-STOCKER > Activities and Due Dates Ch i2 Homework 9/10/2018 11 59 PM O 10 8/15 () 9/4/2018 04:38 PM Gradebook Print Question 18 of 18 eratosis congenita (DKC) is a rare genetic disorder characterized by abnormal fingernails and skin Mapf pigmentation, the formation of white patches on the tongue and cheek, and progressive failure of the borler autosomal dominant form of DKC results fröm mutations in the gene that encodes the RNA component of telomerase Tom Vulliamy and his colleagues ex 2004, Nature Genetics 36:447-449). They observed that the median age of onset years, whereas the median age of onset in the children of affected parents was 14.5 these families arose at progressively younger ages in successive generations, a phenomenon known as anticipation amined 15 families with autosomal dominant DKC (T Vuliamy et al., of DKC in parents was 37 years. Thus, DKC in The researchers measured telomere length of members of these families, the measurements are given in the adjoining table. Telomere lengt age. Note that the age-adjusted telomere length of all members of these families is negative, indicating that their telomeres are shorter than normal. For the shorter the telomere. th normally shortens with age, and so telomere length was adjusted for age-adjusted telomere length, the more negative the num Parent Child 4.7 How do the telomere lengths of parents with DKC compare with the telomere lengths of their children with DKC? 6.6 6.0 0.6 -2.2 O Parents, on average, have longer telomeres than their children. O Parents, on average, have telomeres of equal length as their children. O Parents, on average, have shorter telomeres than their children 3.9 1.4 -5.2 3.6 44 -2.0 6.8 Question continues, Scrol down -5.0 -5.3 6.4 ExilExplanation / Answer
Q.18
THE TELOMERE LENGTH OF PARENT WITH DKC COMPARE WITH TELOMERE LENGTH OF CHILDREN WITH DKC IS PARENTS ON AN AVERAGE HAVE SHORTER TELOMERE LENGTH THEN THE CHILDREN. THE AVERAGE FOR PARENT IS -3.31 AND FOR CHILDREN IS -4.5
LAST PART
THE STATEMENT REGARDING THE ANTICIPATION SHOWN BY DKC IS DKC BECOME MORE SEVEREVIN OFFSPRING DUE TO FAULTY RECOMMBINATiON EVENTS ENVOLVING ABNORMAL TELOMERASE INHERITED FROM PARENTS
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