Degradation specificity is conferred by the E1 ubiquitin ligase. Which statement

Question

Degradation specificity is conferred by the E1 ubiquitin ligase.

Which statement about protein folding is TRUE? Amino acids cluster in the primary sequence so that all the hydrophobic amino acids are near each other to facilitate folding into the hydrophobic core of the tertiary structure. Amino acids with hydrophobic, nonpolar side chains stabilize the tertiary structure through hydrogen bonding with water molecules surrounding the proteins. All known proteins have well-ordered conformations. Elements from the secondary structure are maintained in the tertiary structure.

Explanation / Answer

1) Amionoacids with hydrophobic , nonpolar sidechains stabilize the tertiary structure through hydrogen bonding with water molecule surrounding the proteins.

2) the 20s core of the proteasome is responsible for substrate recognigation prior to degradation.

3) SDS-PAGE >membrane transfer>antibody incubation>detection.

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