1. Other diseases of organelles include lysosomal storage diseases and mitochond

Question

1. Other diseases of organelles include lysosomal storage diseases and mitochondrial disorders. Which major cellular functions are lost in these disorders?

2. How are mitochondria inherited? (Maternally, paternally or from both parents?)

3. Recently, reproductive technologies that use genetic material from three parents to avoid mitochondrial diseases have been reported. On OMIM, identify the genes associated with Leigh syndrome and their modes of transmissions. Which of the conditions can be corrected through mitochondrial transplantation?

4. Is ATP synthase (from the question above) monomeric, homo-oligomeric or hetero-oligomeric?

5. Given that the symptoms of diseases associated with defects in organelles tend to overlap, develop a cellular/molecular strategy for distinguishing defects affecting the three organelles from one another.

6. Trace the secretory pathway in eukaryotic cells and highlight the major molecular activities of each stage.

Explanation / Answer

1. Lysosomal disorder will lead to deficiency in lysosomal and non lysosomal proteins. And coming to mitochondrial disease it means disease associated with mitochondria which is a energy factory of a cell. Cells may fail to oxidise fats and carbohydrates in absence of the mitochondria.

2. Mitochondria are inherited from maternally.

4. It's monomeric.

Related Questions

Navigate

• Browse (All)
• Browse 1
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.