Endomesoderm Specification 6-18 Hours January 09, 2015 This model is frequently
ID: 141106 • Letter: E
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Endomesoderm Specification 6-18 Hours January 09, 2015 This model is frequently revised. It is based on the latest laboratory data, some of which is not yet published Additional data sources for selected notes: 1: McClay lab; 2: Angerer lab; 3: McClay lab Maternal Inputs t G-cadherin GSK-3frizzled Ubiq PMC tch Mat SoxB Mat cß Mat Wnt6 Mat Hnf 6 Nucl. frizzled GSK-3 frizzled n B RhoA Ubiq la lb Wnt8 unkn mes/end rep Ubiq nB-TCF Blimpl SoxB1 Ubiq Ub SoxC Pmari H Hesc HesC ES Wnt8 Hoxl1/13b Eve Wnt8 Eve Gcmp Pmarl r11pm Delt y(2) Ubiq SU(H) rllpm Su(H): la lb 0tx Blimpl Notch Gene X Nrl Tel ErgHex GataE FOXA ra FoxN2/3 Gcm z166 Krl Dri NSM Hnf 6 Veg2 Vegl Su(H:NIC Skel Small Mic Endo Endo 16 SU(H) Sm50 Msp130 Msp-L Ubiq G-cadherin Ficolin Cyp SoxE FoxY Notch unkn SM rep HesC Ubiq-ubiquitous; Mat maternal; activ activator, rep repressor; unkn unknown, Nuc nuclearization; x- B-catenin source; nB-TCF nudearized b-ß-catenin-Tcf1; ES early signal; ECNS early cytoplasmic nuclearization system; Zyg. N. -zygotic Notch Copyright 2001-2015 Hamid Bolouri and Eric DavidsonExplanation / Answer
B lymphocyte–induced maturation protein-1 (Blimp-1), a zinc-finger motif, that was discovered 16 years ago,and is encoded by the positive regulatory domain 1 gene (Prdm1) found in humans.
Blimp-1 is a transcriptional repressor of the IFN promoter and plays fundamentally important roles in many cell lineages and in early development.The protein binds specifically to the PRDI (positive regulatory domain I element) of the -IFN gene promoter.
if there is a knock down of Blimp-1 gene, then it will result into lethal fates in mice because the expression of Blimp-1 is dynamic in primordial germ cells ( in the earliest stage of development).and is critical for mouse embryonic development and plays essential roles in multiple hematopoietic lineages.
Role of Blimp-1 in Human disease
Therefore, BLIMP-1 functions as a gatekeeper of T cell activation and suppression to prevent or dampen autoimmune disease, antiviral responses and antitumor immunity.
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