3 Give your responses to the following questions: Describe the function of alcoh

Question

3 Give your responses to the following questions: Describe the function of alcohol dehydrogenase and the pathway of ethanol metabolism in humans. How many grams can be detoxsified by this pathway per hour? How many grams of alcohol can lead toa hang over What are the short and long terms mental and physical health implications of alcohol abuse? Remember that addressing the issues asked for, using proper grammar & complete sentences, and showing a grasp of the concepts and material discussed is required. Points earned for this discussion are based on content, organization, and proper grammar. Your initial post must be posted by

Explanation / Answer

Alcohol (ethanol or ethyl alcohol) is readily absorbed by the stomach and intestine.Consequently, less than 2% of the alcohol consumed is excreted through lungs, urine and sweat.

Alcohol gets oxidized in the liver by alcohol dehydrogenase to acetaldehyde.  

CH3-CH2-OH -----------------------> CH3CHO

Acetaldehyde Besides ADH, microsomal ethanol oxidizingsystem (MEOS) is also involved in the metabolism of alcohol.

CH3CHO -----------------> CH3COOH

Aldehyde, produced by the action of either ADH or MEOS, is responsible for the manifestations of alcohol The enzyme aldehyde dehydrogenase converts aldehyde to acetic acid which then enters Krebs cycle in the form of acetyl coA.

Since the activity of aldehyde dehydrogenase is less than that of alcohol dehydrogenase, acetaldehyde accumulates leading to various complications.

7 grams per hour is the rate of detoxification of alcohol

Physical symptoms:

Headache;

Muscle soreness;

Thirst

Sensitivity to light and sound;

Drowsiness and fatigue;

Nausea;

Increased systolic blood pressure;

Rapid heartbeat;

Tremor;

Sweating;

Diarrhoea;

Loss of appetite; and

Red eyes.

Mental symptoms

The mental symptoms of a hangover can include:

Dizziness;

Vertigo;

Irritability;

Changes to visual perception;

Poor performance on identification tasks;

Difficulty paying attention, staying alert, reacting and processing information;

Reduced coordination, including hand–eye and limb coordination;

Poor memory and recall; and

Poor performance with task-driven activities

40-50gm of alcohol causes hangover symptoms

Effects of chronic alcoholism:

Chronic alcoholism is associated withcirrhosis of liver, neurodegenerative changes,cardiomyopathy, diuresis, impotence etc

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