The use of specific inhibitors of key metabolic enzymes has provided significant
ID: 140576 • Letter: T
Question
The use of specific inhibitors of key metabolic enzymes has provided significant insight into the function and regulation of metabolic pathways The table below shows unmatched metabolic enzymes and protein activities (in the first column) and inhibitors (in the second column). ENZYME / PROTEIN ACTIVITY INHIBITOR i. hexokinase Ul V. 2-deoxyglucose W. fluoride X. oligomycin A Y. UK-5099 Z. dehydroepiandrosterone (DHEA anide lucose 6-phosphate d mitochondrial enase te carrier iv. enolase V. ATP synthase vi tochrome c oxidase (complex I Which of the options below correctly matches metabolic enzymes/protein activities with the correct inhibitors? a) and V: ii and Z: ii and U: vi and y b) and V: ii and X: i and y: v and X c) and V: iii and Y: v and X; vi and U d) and V: ii and W: iv and U: v and Z e) and V: iv and W: v and U: vi and YExplanation / Answer
(c )2-deoxyglucose is an inhibitor of hexokinase( it competitively inhibits the production of glucose-6- phosphate from glucose
UK-5099 is an inhibitor of mitochondrial pyruvate carrier.
oligomycin A is an inhibtitor of ATP synthase( it blocks proton channel F0 subunit which required for oxidative phosphorylation of ADP to ATP ( ENERGY PRODUCTION)
cyanide is an inhibitor of cytochrome c oxidase(it blocks both ATP producation and cellular O2 utilization by binding with heme a3-CuB binuclear center.
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