Trinucleotide repeat diseases are characterized by premutations, and disease mut

Question

Trinucleotide repeat diseases are characterized by premutations, and disease mutations. Each characterized by the size of the trinucleotide repeats. Which of the following best describes the phenotypes of individuals affected by these diseases?

A. Premutations can eventually progress to active disease.

B. Age of onset increases with increasing size of the trinucleotide repeats.

C. Severity of the phenotype increases with increasing size of the trinucleotide repeats.

D. All of the above are correct.

Explanation / Answer

B. Age of onset increases with increasing size of the trinucleotide repeats

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