42) The first three enzymatic reactions of ?-oxidation of fatty acids carry out

Question

42) The first three enzymatic reactions of ?-oxidation of fatty acids carry out the same sequence of reactions as which of the following enzymes, respectively?

         A) aconitase, isocitrate dehydrogenase, and ?-ketoglutarate dehydrogenase

         B) ?-ketoacyl-ACP reductase, ?-hydroxyacyl-ACP dehydratase, and enoyl-ACP reductase

         C) citrate synthase, aconitase, and isocitrate dehydrogenase

         D) glyceraldehyde 3-P dehydrogenase, phosphoglycerate kinase, and phosphoglycerate mutase

         E) succinate dehydrogenase, fumarase, and malate dehydrogenase

Explanation / Answer

Option B

Enzymes in Fatty acid biosynthesis.

1. condensaton with acetate: beta-ketoacyl-ACP synthase

2. reduction of carbonyl to hydroxyl:beta-ketoacyl-ACP reductase

3. Dehydration of alcohol to alkene: beta-hydroxyacyl-ACP dehydratase

4. reduction of alkene to alkane: enoyl-ACP reductase

5. chain transfer / charging: malonyl CoA-ACP transferase

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