A Case Study of Memory Loss in Mice Michael S. Hudecki Department of Biological

Question

A Case Study of Memory Loss in Mice Michael S. Hudecki Department of Biological Sciences University at Buffalo, State University of New York Please read the following abstract of an article in the New York Times and prepare a short written addressing each of the following questions. response Memory Loss in Mice A biochemist, Eugene Roberts, and researchers at the City of Hope Medical Ctr. [in Duarte, California] discovered that injecting fragments of a brain protein called beta-amyloid into the brains of mice caused the mammals to forget chores they had just been taught U.F Flood et al. Amnestic effects in mice of four synthetic peptides homologous to amyloid B protein from patients with Alzheimer disease. Proc. Nat. Acad. Sci., USA, 88(8):3363-6, Apr 91]. This is really the first correlation between the presence of [beta-amyloid] in the brain and the loss of memory," said Rachael Neve, a molecular biologist at U. California at Irvine. Questions 1. State in concise terms the problem being investigated. 2. Describe the details if any of the experimental method apparently used in this study. 3. Describe any pertinent results that originate from the study. 4 What specific conclusions can you draw from this study? Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Originally published August 7, 2001. Plcase see our usage guidelines, which outline our policy concerning permissible reproduction of this work Photo Alex Ishchenko Dreamstime.com.

Explanation / Answer

Answer-1: Beta-amyloid protein present in mice brain caused them memory loss.

Answer-2: A study was carried out to find out the amnestic effects in mice by administering 4 homologous proteins of beta amyloid protein, extracted from alzheimer's disease patient.

Answer-3: This study showed that presence of beta amyloid in the brain caused memory loss.

Answer-4: Beta amlyloid proteins forms plaque in the brain that further forms neurofibrillar mesh which result in neurodegeneration and that inturn causes memory loss.

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