100 Grade Partl: Protcins sorting, endomembrane system and peroxisomes l. For ea

Question

100 Grade Partl: Protcins sorting, endomembrane system and peroxisomes l. For each of the following proteins, indicate whether the synthesis will be completed on free ribosomes (F-Rib) or ER-bound ribosomes (ER-Rib). a. Mitochondrial proteins b. Lysosomal proteins. c. ER proteins. d. Plasma membrane proteins. e. Peroxisomal proteins. f. Nuclear proteins. g. Golgi proteins. h. Secreted proteins. i. Cytosolic proteins. j. Ribosomal proteins 2. The final cellular localization of a protein is dictated by its 3. The sequence tethers the transcriptional complexes to the ER membrane. 4. A proteins remain in the ER if it possesses a(n) 5. A protein that has no sorting signal will end up in the 6. A single-pass transmembrane protein without an N-terminal ER signal sequence has an internal signal

Explanation / Answer

1.

a. F-Rib

b. ER-Rib

c. ER-Rib

d. ER-Rib

e. F-Rib

f. F-Rib

g. ER-Rib

h.ER-Rib

i. F-Rib

j. F-Rib

2. The final cellular localization of a protein is dictated by its sorting signal.

3. The signal sequence tethers the translational complexes to the ER membrane.

4. A protein remains in the ER if it possesses a  KDEL signal.

5. A protein that has no sorting signal will end up in the extracellular space.

6. A single-pass transmembrane protein without an N-terminal ER signal sequence has an internal stop transfer sequence.

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