40) You are examining the human pedigree shown below and want to determine if th

Question

40) You are examining the human pedigree shown below and want to determine if the rare dominant disease allele (D) is linked to a specific RFLP fragment you are using as a molecular marker. Parental and progeny genotypes and phenotypes are indicated. Note that the father is a dihybrid at both loci, but the mother is homozygous recessive at both loci. Assume complete penetrance of the trait and a linkage phase of D-R1/d-R2 in the father. What is the recombinant frequency? D/d,R1/R2 did,R1/R1 E) 25% C)50% D) 5% A)75% B) 1096

Explanation / Answer

Recombination frequency is calculated by the formula,

= total number of recombinant offsprings / total number of offsprings

= 2/8

= 0.25

= 25%

(option E)

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