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A mutation can sometimes result in a partially functional protein that still has

ID: 134544 • Letter: A

Question

A mutation can sometimes result in a partially functional protein that still has some activity, and can be beneficial to an organism depending on the right environmental conditions. e. 24. Which types of inheritance may skip generations? a. autosomal dominant b. autosomal recessive c. inbreeding d. penetrance e. X-linked dominant 25. Sickle cell anemia is caused by a. a single nucleotide mutation in DNA b. a frameshift mutation c. a double nucleotide mutation in RNA d. exposure to sunlight e. exposure to chemical substances 26. Hemoglobin is made up of a. Two identical protein chains. b. Two different protein chains. c. Three different protein chains. d. All of these. e. None of these. 27. Which of the following statements is true about RNA polymerase? a. RNA polymerase binds to promoter sequences in DNA to begin transcription. b. RNA polymerase uses nucleotides containing deoxyribose as the sugar. c. RNA polymerase uses a DNA template to make tRNA. d. RNA polymerase stops making new DNA sequences when it encounters a RNA polymerase uses the DNA template to make more DNA. e. 28. How might a change in DNA nucleotide cause a genetic disorder? a. A change in one base pair in a gene can change a crucial amino acid in a protein. A mutation can change the three-dimensional shape of a protein and cause defective protein folding. A mutational change can cause a protein's subunits not to couple with each other properly b. c. d. The DNA can lead to a change in the amount of enzyme produced. e. All of these are possible ways that changes in DNA could lead to genetic disorders.

Explanation / Answer

24) Answer is Autosomal Recessive because both the recessive copies of the gene are to be inherited, one each from father and mother for the trait to show. And if only one copy of recessive gene is present, then the person could be a carrier for the trait, which means the person does not show the gene related trait.

25) Answer is a single nucleotide mutation in DNA - substitution of a single nucleotide in the beta-hemoglobin gene causes sickle cell anemia. Valine is produced because of substitution in the place of glutamic acid.

26) Answer is None of the above because hemoglobin is made up of four protein chains: two alpha chains and two beta chains. Each protein chain consists of a heme group to which an iron atom is attached. This each heme group can reversibly bind one oxygen molecule, which means one hemoglobin molecule can bind to four oxygen molecules

27) Answer is RNA polymerase binds to promoter sequences in DNA to begin transcription - To initiate transcription (initial step of gene expression), RNA polymerase binds to promoter regions found in the DNA, to separate and provide single-stranded DNA template necessary for transcription.

28) Answer is All of these are possible ways - all the reasons mentioned are causes of genetic disorders due to changes in DNA nucleotide.

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