Which of the following statements about enhancers is NOT true? RNA polymerase Il

Question

Which of the following statements about enhancers is NOT true? RNA polymerase Il binds enhancers to initiate transcription. Factors that bind enhancers are important for recruiting factors that facilitate transcription Genes can have more than one enhancer to ensure that transcription occurs in the right location and time during embryonic development. O The transcription factors that bind enhancers during development often change as regions of the organism become more specifically defined. Enhancers can be bound by transcription factors to activate or repress transcription

Explanation / Answer

RNA polymarase II binds to enhancers to initiate transcription - False

Not RNA polymerase, but transcription factors or activators bind to enhancers to turn on a specific gene.

Factors that bind enhancers are important for recruiting factors that facilitate transcription - True.

Genes can have more than one enhancer to ensure that transcription occurs in the right location and time during embryonic development - True

The transcription factors hat bind enhancers during development often change as regions of the organism become more specifically defined - True.

In mouse, Tbx4 gene has a number of enhancers. Some regulate the formation of hind leg, some umbilical cord etc.

Enhancers can be bound by transcription factors to activate or repress transcription - False

Enhancers can activate transcription only. Silencers repress transcription.

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