True or False [ ] Once inside cells, fatty acids are activated at the outer mito

Question

True or False

[ ] Once inside cells, fatty acids are activated at the outer mitochondrial membrane by conversion to fatty acyl-CoA thioesters. Fatty acyl-CoA that is to be oxidized enters mitochondria directly by diffusion.

[ ] Chylomicrons deliver triacylglycerols to tissues, where lipoprotein lipase releases free fatty acids for entry into cells.

[ ] Malonyl-CoA, an early intermediate of fatty acid synthesis, inhibits carnitine acyltransferase I, preventing fatty acid entry into mitochondria.This blocks fatty acid breakdown while synthesis is occurring.

[ ] The reactions of ? oxidation, occurring in the endoplasmic reticulum, produce dicarboxylic fatty acyl intermediates, which can undergo ?-oxidation at either end to yield short dicarboxylic acids such as succinate.

[ ] The reactions of ? oxidation degrade branched fatty acids such as phytanic acid.

[ ] In the first stage of ? oxidation, three reactions remove each acetyl-CoA unit from the carboxyl end of a saturated fatty acyl-CoA: (1)dehydrogenation of the ? and ? carbons (C-2 and C-3) by NAD-linked acyl-CoA dehydrogenases, (2) hydration of the resulting trans -? 2 double bond by enoyl-CoA hydratase, (3) dehydrogenation of the resulting L-?-hydroxyacyl-CoA by FAD-linked ?-hydroxyacyl-CoA dehydrogenase. The shortened fatty acyl-CoA then reenters the sequence.

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