Our ability to recognize a wide range of antigens depends upon the generation of
ID: 132424 • Letter: O
Question
Our ability to recognize a wide range of antigens depends upon the generation of a wide variety of immune receptors. This occurs through a process called VDJ recombination, where different combinations of DNA (the V,D, and J sequences) are shuffled to make random receptors. Adenosine deaminase is an enzyme required in this process, without which functional immune receptors cannot be created. What cells would be absent or defective in a patient lacking a functional adenosine deaminase?
a)B-cells b)CD4+ Helper T-cells c)CD8+ Killer T-cells d)Macrophages e)Mast Cells f)Neutrophils g)None
Explanation / Answer
Answer: Options A and C are correct.
Explanation:
VDJ recombination: Recombination of Variable, Diversity, and Joining regions.
It is a somatic recombination process.
It occurs during the development of B-cells and CD8+ T cells.
It is a characteristic feature of the adaptive immune system which produces a highly diverse repertoire of antibodies and TCRs.
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