uestion 10 (1 point)G The rate of glycolysis in the liver may regulated by pyruv

Question

uestion 10 (1 point)G The rate of glycolysis in the liver may regulated by pyruvate kinase if which of the following conditions are met or, choose the best no possible way rationale no conditions are possible because pyruvate kinase is not a regulated enzyme pyruvate kinase regulates the rate if the cytosolic concentration of fructose 1,6 2, 2) bisphosphate is high 3) glucose is initial substrate and energy charge is low no conditions are possible because PFK governs the rate of glycolysis both in 4) low and high energy charge s pyruvate kinase regulates the rate of glycolysis in liver if fructose is the initial 5) substrate

Explanation / Answer

2) pyruvate kinase regulates the rate if the cytosolic concentration of fructose 1,6 bisphosphate is high

Fructose 1,6 bisphosphate binds to the allosteric binding site of pyruvate kinase and causes a change in the conformation of the enzyme. This leads to the activation of pyruvate kinase activity.

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