The production of ROS can be reduced using drugs that allow protons to freely pa
ID: 132080 • Letter: T
Question
The production of ROS can be reduced using drugs that allow protons to freely pass through the inner membrane. The effect of a drug called DNP on the life span of mice is shown in the graph below. Each point represents the death of a single 100 80 Control 60 DNP 40- 20 20 40 60 80 100 120 140 Age (weeks) Souce. C. c. Caldera da Slvaeta. 200e. ngng Cev 7 5520-560. How could you determine i he mitochondri! E C ls affected n DNP treated mce? Propose an experiment o determine Drag the tems on the left to the appropriate blanke on the right to complete the sentences there is?co relation between ife span end ETC acti ty n mitochonana so ated from mice used n he experiment above Reset Help citrate Isclated mitochondia from either DNP-trated mice or control mic couk be treat ted with the pyruvate eouril of ATP prodiuced could be determined itDNP Is reduring the proton gradient, you would expec The ariounl o less ATP to be produced from thes mitochondria compared to those obtained from the control miceExplanation / Answer
DNP (Dinitrophenol) is an inhibitor of oxidative phosphorylation. It does not inhibit any of the components of the electron transport chain. However, it increases the fluidity of the inner mitochondrial membrane for protons. So, protons easily diffuse through the inner mitochondrial membrane thereby dissipating the proton gradient created by NADH and FADH2. Hence it results in the uncoupling of proton gradient from oxidative phosphorylation. Due to this property, it is called an uncoupler.
It was used as a therapeutic to reduce weight as energy(ATP) is not produced by the NADH and FADH2. It was discontinued later due to several reasons such as the production of excess heat in the body.
Answer:
1. Citrate: Citrate is a metabolite of TCA cycle from which ATP can be generated in the mitochondria.
2. Less
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