A Merck representative visits your office and tells you that Fosamax (alendronat

Question

A Merck representative visits your office and tells you that Fosamax (alendronate) will decrease the incidence of repeat hip fracture by 50% over 3 years. That excites you because you have 20 elderly women and 5 elderly men who already have fractured one hip in your practice. You locate the study by Black in Lancet (1996) and find out that fracture occurs in 2.2% of placebo patients and 1.1% of patients on Fosamax. The daily cost for generic alendronate is $0.21. Calculate the COPE for this generic name drug if the number of years treated is 3 years. Round to the nearest whole dollar.

Explanation / Answer

The values we have at hand:

The Experimental Event Rate is: 1.1%

The Control Event Rate (CER) is: 2.2 %

The Absolute Risk Reduction = ARR can be established by using ARR = EER-CER

On Fosamax, 1.1% (EER) and 2.2% (CER) on placebo

So the ARR will be = 1.1% -2.2%= -1.1

The Absolute Risk Reduction is: 1.1

The Amount obligatory to Treat, also known as (NNT) can be instituted by means of the calculation: NNT = 100/ARR.

Therefore: 100/1.1= 90.90

The NNT is 91

To compute one tab or pill of 70 mg amount of Fosamax at $170.21 for four pills it is indispensable division by 4.

$170.21/4= $42.5525 pointed to the adjacent dollar it is $43.00 for one pill.

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