_____23. This type of diuretic primarily reabsorbs sodium and chloride in the lo

Question

_____23. This type of diuretic primarily reabsorbs sodium and chloride in the loop of Henle and proximal and distal tubules.

a. Mannitol

b. Loop diuretics

c. Thiazide diuretics

d. K+ sparing diuretics

_____24. This drug has better bioavailability compared to gabapentin

a. Tizidine

b. Lorazepam

c. Baclofen

d. Pregabalin

_____25. This is the first line drug for acute gout

a. Corticosteroids

b. Chloroquine

c. NSAIDs

d. Coxibs

_____26. This has the very little anti inflammatory effect or none at all.

a. Coxibs

b. Acetaminophen

c. ASA

d. t-NSAIDs

_____27. This drug inhibits xanthine oxidase in the use for acute gout

a. Probenecid

b. Sulfinpyrazone

c. Allopurinol

d. t-NSAIDs

_____28. This drug weakly inhibits COX-1 and COX-2 causing poor anti-inflammatory effect.

a. t-NSAIDs

b. acetaminophen

c. corticosteroids

d. DMARDs

Explanation / Answer

23. B

Loop diuretics act on the Na+-K+-2Cl symporter , Loop diuretics are diuretics that act at the ascending limb of the loop of Henle in the kidney.

24. D

Gabapentine BA is max 30% at high dose

Tizidine BA is 80%

Lorazepam BA 77.7%

Baclofen BA 80%

Pragabalin >/= 90%

25: C (NSAIDS)

26: B (Acetaminophen)

Acetaminophen is a pain reliever and a fever reducer. Remaining are definately shows anti-inflammatory action

27: C (Allopurinol)

Allopurinol, sold under the brand name Zyloprim among others, is a medication used to treat gout.  Allopurinolis in the xanthine oxidase inhibitor family of medications

28: C

Corticosteroids appear to be due to DNA binding and gene activation (cis-repression), whereas anti-inflammatory effects are predominantly due to inhibition of inflammatory gene expression by NF-B.

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