60. In the dynamic instability model, why does loss of the GTP cap cause rapid d
ID: 11303 • Letter: 6
Question
60. In the dynamic instability model, why does loss of the GTP cap
cause rapid disassembly? A complete answer should explain why
hydrolysis causes protofilaments to bend and why GDP subunits in
the bent protofilaments have an extremely high rate of dissociation
from polymer. Note: this question is NOT asking about critical
concentrations. It’s about the structure of the MT plus end and what
holds the subunits in the polymer lattice together.
60. In the dynamic instability model, why does loss of the GTP cap cause rapid disassembly? A complete answer should explain why hydrolysis causes protofilaments to bend and why GDP subunits in the bent protofilaments have an extremely high rate of dissociation from polymer. Note: this question is NOT asking about critical concentrations. It?s about the structure of the MT plus end and what holds the subunits in the polymer lattice together.Explanation / Answer
Microtubule is asymmetric in assembly.
Positive end of Microtubule ,of tubulin dimer ,dissociate faster than negativeend of Microtubule.
The decrease of tubulin dimers concentration - Positive end of Microtubule ,of tubulin dimer --------leads to loss of GTP CAP
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