Phenylketonuria (PKU) is a human hereditary disorder that prevents body from pro

Q: Phenylketonuria (PKU) is a human hereditary disorder that prevents body from pro

FROM THE GIVEBN INFORMATION , BY DOING PEDIGREE ANALYSIS Man heterozygous for PKU-------------Pp Women heterozygous for PKU-------------Pp Pp x Pp P p P PP-------NORMAL HOMOZYGOUS Pp ------ NORMAL HETEROZYGOUS p Pp ------ NORMAL HETEROZYGOUS pp -AFFECTED Answer --------1/4= 25% P p P PP-------NORMAL HOMOZYGOUS Pp ------ NORMAL HETEROZYGOUS p Pp ------ NORMAL HETEROZYGOUS pp -AFFECTED

ID: 11013 • Letter: P

Question

Phenylketonuria (PKU) is a human hereditary disorder that prevents body from processing the amino acid phenylalanine. PKU is manifested in early infancy and if remain untreated, generally cause mental retardation. PKU is caused by a simple Mendelian recessive allele.
A couple intends to have children but consults a genetic counselor because the man has a sister with PKU and a woman has a brother with PKU. There are no other known cases in both families. They ask the genetic counselor to determine the probability that their first child will have PKU.
What is this probability?

Explanation / Answer

FROM THE GIVEBN INFORMATION , BY DOING PEDIGREE ANALYSIS

Man heterozygous for PKU-------------Pp

Women heterozygous for PKU-------------Pp

Pp x Pp

PP-------NORMAL HOMOZYGOUS

Pp ------ NORMAL HETEROZYGOUS

pp -AFFECTED

Answer --------1/4= 25%

PP-------NORMAL HOMOZYGOUS

Pp ------ NORMAL HETEROZYGOUS

pp -AFFECTED

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Phenylketonuria (PKU) is a human hereditary disease resulting from the inability

Phenylketonuria (PKU) is an inherited disease caused by a recessive allele. If a

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Phenylketonuria (PKU) is a human hereditary disorder that prevents body from pro

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