ost erse group of molecules which have broad biological applications. One of the
ID: 1089038 • Letter: O
Question
ost erse group of molecules which have broad biological applications. One of their as antimicrobial agents. Efficacy can be altered by varying the substituents attached to th Consider the following condensation reaction to produce this chalconse ease er the following questions regarding the synthesis below NaoH H3sco CH3 +H20 H3C Ethanol 1, 4-methoxybenzaldehyde 2, 4'-methylacetophenone b.p. 248°C 3, chalcone product m.p. 95°C m.p.34 °C The above reaction was run 4 times under 4 separate sets of reaction conditions, as depicted by the following 4 TLC plates shown below. Lane l = starting material 1 . Lane 2 # starting material 2 The reaction lane represents what is in the reaction mixture AFTER the workup for each reaction. In which reaction(s) would recrystallization be an appropriate means of purification (select all that apply)? Justify your answer thoroughly in words. (5 points) i· Reaction #1 Reaction #2 Reaction #3 Reaction #4 "--!Explanation / Answer
From the TLC we can conclude the reaction progress:
TLC for reaction on shows that both the reactants (4-methoxybenzaldehyde and 4-methoxybenzaldehyde) as well as some amount of reaction product are present and reaction is not complete .So the recrystallization is not completely pure.
For reaction 2 TLC first reactant is not present in the final solution but second reactant is present with the product so the recrystallization is not pure.
For thirsreaction TLC in reaction solution first reactant and product is present this the recrystallization is not pure.
For reaction 4: in the final reaction solution only product is present and the recrystallization process gives pure crystals of chalcone product.
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