You are working on an improved polypropylene (–[CH2-CHCH3]n-) hernia correction

Question

You are working on an improved polypropylene (–[CH2-CHCH3]n-) hernia correction mesh that releases an anti-inflammatory drug after implantation and is coated with type I collagen to promote bio-recognition to promote tissue integration.

How would you characterize the polypropylene, including backbone chemistry, molecular weight distribution and stereochemistry?

How would you determine if the polypropylene is crystalline and, if so, the crystal structure of the polypropylene?

How would you prove the coating is type I collagen?

How would you determine the chemistry and concentration of the drug?

Explanation / Answer

Molecular weight distrubution can be calculated by mass spectroscopy, light-scattering and below formula

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