Please help me with this. The effect of gramicidin on oxidative phosphorylation

Question

Please help me with this.

The effect of gramicidin on oxidative phosphorylation When the protein gramicidin is integrated into a membrane, an H^+ channel forms and the membrane becomes very permeable to protons (H^+ ions). If gramicidin is added to an actively respiring muscle cell, how would it affect the rates of electron transport proton pumping and ATP synthesis in oxidative phosphorylation? (Assume that gramicidin does not affect the production of NADH and FADH_2 during the early stages of cellular respiration.) Sort the labels into the correct bin according to the effect that gramicidin would have on each process.

Explanation / Answer

Remains the same -Rate of oxygen uptake,proton pumping rate, electron transport rate

decreases-Size of proton gradient and rate of ATP synthesis

Membranes become very leaky to protons due to Gramicidin, so that a proton gradient cannot be maintained and ATP synthesis stops. However, the leakiness of the membrane has no effect on the ability of electron transport to pump protons. Thus, the rates of proton pumping, electron transport, and oxygen uptake remain unchanged.

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