During exercise, when ADP concentrations are high and ATP concentrations are low

Question

During exercise, when ADP concentrations are high and ATP concentrations are low in the cell, the regulated enzymes of glycolysis are ___ at step ___. inhibited, 3 inhibited, 10 stimulated, 6 stimulated, 9 none of the above The molecule to the right is involved in the citric acid cycle. What is its IUPAC name? hydroxybutanedioate 2-oxopentanedioic acid propyl ethanoate malate alpha-ketogluterate An enzyme that converts a ketone to a 2 degree alcohol is classified as a(n) transferase lyase hydrolase isomerase oxidoreductase

Explanation / Answer

160. Cellular isozymes of pyruvate kinase are allosterically inhibited by high concentrations of ATP. During strenuous exercise, the NADH formed in the glyceraldehyde 3-phosphate dehydrogenase reaction in skeletal muscle must be reoxidized to NAD+ if glycolysis is to continue. phosphofructokinase (PFK-1) is an allosteric enzyme that occupies the key regulatory position for glycolysis. The enzyme has two binding sites for ATP. One is the substrate binding site and the other one is an inhibitory site. High concentrations of ATP shift the equilibrium towards the T conformation which decreases the affinity of the enzyme for F-6-P. AMP reverses the inhibition due to high concentrations of ATP. This is important the concentration of ATP drops only 10 % during vigorous exercising. AMP concentration levels in the cell can rise dramatically due to the enzymatic activity of adenylate kinase.

Answer: C) stimulated,6

161.) Answer: B) 2-oxopentanedioic acid

162.) E) oxidoreductase    - Which catalyze oxidation or reduction

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